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In addition to the Japan-only rights to the 13 drugs, Takeda is buying a share of the worldwide rights to an Amgen cancer drug under development, motesanib diphosphate, also called AMG 706.

Yet even as the two establishment candidates huffed and puffed to assert their authority, they seemed terrified by Mr. Obama’s insurgency, as if it were the plague in Edgar Allan Poe’s “Masque of the Red Death.” Mrs. Clinton held her nonconcession speech in a Manhattan bunker, banishing cellphone reception and television monitors carrying the news of Mr. Obama’s clinching of the nomination. Mr. McCain, laboring under the misapprehension that he was wittily skewering his opponent, compulsively invoked the Obama-patented mantra of “change” 33 times in his speech.